Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
نویسندگان
چکیده
منابع مشابه
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable co...
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T he current treatment for medulloblastoma—resection, radiation, and chemotherapy—negatively affects neurocognitive development and fails to ensure survival beyond 10 years for about 40% of children. Among the 4 molecular subtypes of this disease, the group 3 subtype has an especially poor prognosis. Recently, Bai and colleagues demonstrated compelling preclinical evidence for using the microtu...
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Chen AM , Farwell DG , Luu Q , Donald PJ , Perks J , Purdy J . [20] Evaluation of the planning target volume in the treatment of head and neck cancer with intensity-modulated radiotherapy: What is the appropriate expansion margin in the setting of daily image guidance? Int J Radiat Oncol Biol Phys 2011 ; 81 : 943 – 9 . Van Herk M , Remeijer P , Rasch C , Lebesque JV . The [21] probability of co...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2014
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-14-0755-t